Bone growth and metabolism are mainly regulated by a series of intracellular molecules and extracellular stimuli. Exosome, as a\nnanoscale substance secreted to the outside of the cells, plays an extensive role in intercellular communication. This review\nprovides theoretical references and evidences for further exploration of exosomes as noncoding RNA carriers to regulate bone\ntissue recovery through the following aspects: (1) basic characteristics of exosomes, (2) research progress of exosomal noncoding\nRNA in bone tissue engineering, (3) current status and advantages of engineering exosomes as nanocarriers for noncoding RNA\ndelivery, and (4) problems and application prospects of exosome therapy in the field of orthopedics.
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